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(2013) Lipoic acid in animal models and clinical use in diabetic retinopathy

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This higher threshold is largely due to larger kidneys and livers relative to body size in children versus adults, and hence greater tolerance of paracetamol overdose than adults.[35] Acute paracetamol overdose in children rarely causes illness or death with chronic, supratherapeutic doses being the major cause of toxicity in children